Effect of Plasmodium Infections on CD4 Cells, Neutrophil and Lymphocytes

Authors

  • Emmanuel Chike Amadi Department of Medical Microbiology, College of Medicine, Enugu State University of Science and Technology, Park Lane Campus, Park Avenue, GRA, Enugu, Enugu State, Nigeria; Department of Microbiology, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria; Department of Microbiology, Caritas University, Enugu, Enugu State, Nigeria
  • Chukwuemeka Chijoke Nwangwu Department of Medical Microbiology, College of Medicine, Enugu State University of Science and Technology, Park Lane Campus, Park Avenue, GRA, Enugu, Enugu State, Nigeria
  • Emmanuel A. Eze Department of Microbiology, Faculty of Biological Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
  • Sylvia Ijeoma Adaugo Anyaehie Department of Medical Microbiology, College of Medicine, Enugu State University of Science and Technology, Park Lane Campus, Park Avenue, GRA, Enugu, Enugu State, Nigeria

Keywords:

CD4 cells, Plasmodium spp, flow cytometry, malaria, immunity

Abstract

Knowledge of malaria-immunity is essential for understanding the pathology, treatment & vaccine production. So, changes in CD4 in malaria patients were studied at a teaching hospital in Enugu, Nigeria. 45 patients on doctor’s provisional diagnosis of malaria were examined for Plasmodium infections and the degree of parasitaemia (0/+/ ++/ & +++). Positive/(+) and negative/(0) samples were thereafter counted for CD4 using Flow Cytometry. CD4 cell count of Plasmodium-negative specimens were within reference ranges (RR): (464-1308); mean value: 835. Fifteen (+) parasitaemia showed lower ranges of CD4 count (502-1282); mean: 678; with immune falls in one (427). 9/12 (++) parasitaemia showed crash in CD4 counts, range: 301- 415; mean: 399. Seven (+++) parasitaemia showed crashes in CD4 counts, range: 160-357; mean: 225. As parasitaemia rises, neutrophils, Total WBC and lymphocyte significantly rise in numeric. Malaria causes immunosuppression; unlike prevailing reports, should accelerate complications in immunodeficients-patients, Haemolytic-anaemia results only from chronic cases. CD4 counts should be a paradigm in malaria investigation.

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Published

2023-11-07

How to Cite

Emmanuel Chike Amadi, Chukwuemeka Chijoke Nwangwu, Emmanuel A. Eze, & Sylvia Ijeoma Adaugo Anyaehie. (2023). Effect of Plasmodium Infections on CD4 Cells, Neutrophil and Lymphocytes. nnovation in cience and echnology, 2(6), 15–20. etrieved from https://www.paradigmpress.org/ist/article/view/856

Issue

Vol. 2 No. 6 (2023): November

Section

Articles