Journal of Innovations in Medical Research

Predictive Value of CCL3 Expression Levels for Therapeutic Response in Patients with Locally Advanced Cervical Cancer

Hang Chen — 2026-04-10

Rationale: Locally advanced cervical cancer (LACC) exhibits profound therapeutic heterogeneity, with therapy resistance heavily influenced by the immunosuppressive tumor microenvironment. The myeloid compartment, particularly tumor-associated macrophages (TAMs), serves as a key mediator of this therapeutic resistance, yet the precise molecular hubs for predicting neoadjuvant chemotherapy (NACT) sensitivity remain insufficiently characterized. Objectives: This study aims to decipher the myeloid-driven mechanisms of chemoresistance and validate the clinical utility of the chemokine CCL3 as a predictive and prognostic biomarker in LACC patients to optimize personalized treatment strategies. Methods: We integrated single-cell transcriptomics (GSE236738) from six LACC patients with high-dimensional Weighted Gene Co-expression Network Analysis (hdWGCNA) to identify macrophage-specific functional modules and hub genes. Subsequent retrospective clinical validation was conducted via immunohistochemistry (IHC) on pre-treatment primary tumor biopsies from a cohort of 33 LACC patients receiving NACT, correlating CCL3 protein expression with RECIST outcomes and survival trajectories. Measurements and Main Results: Single-cell analysis revealed a substantial expansion of macrophages, accounting for approximately 35% of the immune infiltrate. hdWGCNA pinpointed the chemokine CCL3 as the central hub gene driving this macrophage functional polarization. In the clinical cohort, elevated CCL3 expression was significantly linked to diminished chemosensitivity and a poor pathological response, characterized by higher median Tumor regression rate (based on RECIST 1.1)s (0.31 vs. 0.57; P = 0.001). Furthermore, univariate Cox regression and Kaplan-Meier analyses confirmed that high CCL3 expression shows potential as a reliable prognostic factor for both reduced progression-free survival (HR = 1.190; P = 0.004) and overall survival (HR = 1.278; P < 0.001). Conclusions: CCL3 is a pivotal orchestrator of macrophage-mediated immune exclusion and chemoresistance in LACC. Assessing CCL3 expression levels provides a promising predictive tool for NACT sensitivity and a vital prognostic indicator, offering actionable insights for developing targeted immunotherapies and advancing precision oncology for LACC management.

Epidemiological Investigation of Hepatitis F Viruses (HFV)

Haradhan Kumar Mohajan — 2026-04-10

The hepatitis is a liver inflammation that is related to hepatocellular necrosis. Viral hepatitis may be caused by various hepatitis viruses, such as A, B, C, D, E, F, and G. Hepatitis F is a hypothetical virus linked to viral hepatitis. Sporadic non-A, non-B hepatitis, such as hepatitis F is the most common, presumed viral that may cause acute liver failure. A novel agent called hepatitis French virus (HFV) was present as 27-37nm particles in the infectious stool extract of French patients. The virology, epidemiology, hepatotropism, and clinical importance of HFV are quite uncertain, and are not determined yet. This study tries to discuss the known structure and other clinical features of HFV.

The “Romance of the Three Kingdoms” of EGFR-TKI Combination Therapy: Relationships Among Efficacy, Toxicity, and Resistance Mechanisms

Binquan Wang — 2026-04-24

Epidermal growth factor receptor (EGFR) mutations is one of the most significant driver genes in non-small cell lung cancer (NSCLC), particularly exhibiting a higher incidence among East Asian non-smokers with adenocarcinoma. The successful research and development of Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) has significantly improved the survival for this patient population. But primary and secondary resistance remain core challenges in clinical practice. To overcome drug resistance, enhance efficacy, and prolong patient survival, targeted combination therapy strategies have emerged and become a research focus. This review provides a systematic review of the latest clinical evidence for EGFR-TKI combination therapy with chemotherapy, anti-angiogenic agents, other signaling pathway inhibitors, immunotherapy, and emerging dual-target therapies (such as bispecific antibodies and antibody-drug conjugates). The results indicate that TKIs combined with chemotherapy or bispecific antibody drugs have become one of the key options for first-line treatment; Precision combinations targeting resistance mechanisms (such as MET) is the developmental direction for subsequent lines of therapy; while the combination of TKIs with immune checkpoint inhibitors requires cautious exploration. In the future, personalized combination strategies guided by dynamic molecular profiling, the development of novel drugs, and the optimization of treatment modalities will be key to further overcoming therapeutic bottlenecks.

The “Triangle Operation” in Pancreatic Cancer: Toward Optimizing Oncological Radicality After Neoadjuvant Therapy

Dr. R. Menoura — 2026-04-28

Recent advances in pancreatic cancer management, particularly with the introduction of intensive neoadjuvant chemotherapy regimens, have significantly reshaped surgical indications and objectives. In this context, the “Triangle Operation,” described by Thomas Hackert, has emerged as an innovative approach aimed at improving R0 resection rates without systematically resorting to arterial resections. This technique is based on an extensive dissection of the peri-arterial compartment located between the superior mesenteric artery, the celiac trunk, and the porto-mesenteric axis. Its primary goal is to eradicate areas of potential microscopic tumor spread, particularly after neoadjuvant therapy. Through a detailed analysis of anatomical foundations, technical principles, and clinical outcomes, this article highlights both the benefits and limitations of this strategy in the management of borderline resectable and locally advanced pancreatic tumors.

Research Progress on the Effects of Immunonutrition on Oral Mucositis and Nutritional Status in Patients with Head and Neck Cancer Undergoing Radiotherapy

Xin He — 2026-04-28

Patients with head and neck cancer (HNC) undergoing radiation therapy (RT) frequently face oral mucositis (OM), a challenging and highly prevalent acute toxic reaction. OM not only causes severe pain, dysphagia, and impaired nutritional intake but also intertwines with malnutrition to form a vicious cycle that is difficult to break, thereby significantly compromising treatment efficacy and patients’ quality of life. While traditional nutritional support can barely maintain basic energy supply, it proves inadequate in modulating the cytokine storm and immune response. In contrast, immunonutrition, as an emerging therapeutic paradigm, attempts to exert “pharmacological-level” regulatory effects by precisely incorporating specific components such as arginine, ω-3 polyunsaturated fatty acids (EPA, DHA), and nucleotides into standard formulas, aiming to suppress inflammation and oxidative stress while providing nutrients. In recent years, the academic community has focused on immunonutritional formulations represented by IMPACT®, deeply exploring their clinical value in the HNC radiotherapy population. This review aims to systematically organize and analyze relevant evidence to discuss how immunonutrition intervenes in the prevention and management of oral mucositis and improves patients’ nutritional status. Existing data suggest that immunonutritional intervention can not only effectively reduce the incidence of severe (grade ≥3) oral mucositis and alleviate its severity and progression but also demonstrate unique advantages in stabilizing patient body weight, lean body mass (muscle mass), and plasma protein levels (albumin, prealbumin), holding promise for breaking the causal chain between malnutrition and mucositis. Its underlying mechanisms may stem from recalibrating the balance of pro-inflammatory/anti-inflammatory cytokines (e.g., downregulating IL-6 and TNF-α while upregulating IL-10), reinforcing the body’s antioxidant defenses, and maintaining lymphocyte count and function. Certainly, existing research results still exhibit heterogeneity, often involving multiple variables such as timing of intervention, dosage range, duration of treatment, subject characteristics, and control settings. Looking ahead, there is an urgent need for more rigorously designed, large-sample multicenter randomized controlled trials, supplemented by in-depth mechanistic exploration and long-term follow-up, to clarify the optimal strategies, cost-effectiveness, and true impact on long-term prognosis of immunonutrition in supportive care for HNC radiotherapy.

Challenges and Optimization Strategies for School-Based Health Interventions in Adolescent Myopia Prevention and Control

Yue Zhang — 2026-04-30

Adolescent myopia has become a major visual health concern closely related to daily learning routines, prolonged near work, limited outdoor activity, and increasing screen use. Schools are an important setting for myopia prevention because they can organize regular screening, provide health education, manage classroom conditions, and influence students’ everyday eye-use behavior. However, the effectiveness of school-based health interventions is often limited by several practical problems. Academic pressure may reduce outdoor activity and prolong continuous near work. Vision screening may not be followed by timely referral and sustained follow-up. Health education may improve awareness but fail to change daily behavior. Uneven resources and weak cooperation among schools, families, and medical institutions may also weaken intervention outcomes. This paper analyzes the main forms and challenges of school-based health interventions in adolescent myopia prevention and control, and proposes optimization strategies from the perspectives of routine school governance, closed-loop screening and follow-up, behavior-oriented health education, school-family-medical collaboration, and improvement of outdoor activity and classroom visual environment. The paper argues that school-based myopia prevention should not rely on isolated campaigns or periodic screening alone. More attention should be paid to connecting existing measures with students’ daily school life, so that prevention becomes a continuous and practical part of visual health management.

Research on the Construction of a Screening and Intervention Service System for Postpartum Depression

Mingyi Zhao — 2026-04-30

Postpartum depression is a common but easily overlooked mental health problem in maternal care. Many women do not actively describe themselves as depressed, and their symptoms may be hidden behind sleep loss, childcare pressure, breastfeeding difficulties, irritability, guilt, or fatigue after delivery. At present, postpartum health services still tend to focus more on physical recovery and infant health, while psychological screening, referral, intervention, and follow-up are not always well connected. This paper discusses the construction of a screening and intervention service system for postpartum depression. It analyzes the service needs of postpartum women, the current gaps in screening and intervention, the design of a screening pathway, the construction of an intervention service pathway, coordination among maternal care, community health, and mental health services, and the supporting mechanisms needed for implementation. The paper argues that postpartum depression care should not stop at one-time screening or general advice. A more effective service system should combine routine screening, risk classification, graded intervention, referral collaboration, family support, privacy protection, and continuous follow-up, so that women at risk can receive timely and appropriate help within the maternal and child health service process.