Journal of Innovations in Medical Research

From Remission and Regression of Diseases to Controlled Normal Life Activity

Evgeniy Bryndin — 2026-05-18

Remission and regression are concepts related to disease dynamics, particularly in oncology, but also used in other areas of medicine. They describe the reduction or disappearance of symptoms and signs of a disease, which can lead to the restoration of normal life. However, it is important to understand that remission does not always mean a complete cure, while regression indicates a stable improvement in a patient’s condition. Upon achieving remission or regression, a patient can gradually return to their normal life, engage in professional activities, interact with different people, and maintain physical activity. Remission and regression are important stages in disease treatment. Modern technologies for disease remission and regression are actively developing in several areas, including cancer, autoimmune, and rheumatic diseases. These include both established methods and innovative approaches based on advances in genetic engineering, immunotherapy, and other technologies. Research into disease remission and regression is an active area of research aimed at improving patient outcomes and developing more effective therapeutic strategies. Research into disease remission and regression spans various fields of medicine, including oncology and endocrinology. Studies show that early and long-term remission improves functional outcomes. Efforts to standardize remission and regression across various fields of medicine are ongoing to improve diagnosis, functional status, and comparison of research results.

A Review of the Physiological Effects of Foam Rolling on Skeletal Muscle

Mingyang Wei — 2026-05-18

As a commonly employed modality for self-myofascial release, foam rolling is widely used in sports rehabilitation and physical training. This article analyzes the physiological effects of foam rolling on skeletal muscle and explores its potential mechanisms. After retrieving PubMed, Cochrane, ScienceDirect, and Embase, and manually screening references, a total of 16 randomized controlled trials, 4 systematic reviews or mechanism reviews, 2 survey studies, and 3 other primary studies were finally included. Available evidence suggests that acute foam rolling is generally associated with improved joint range of motion, whereas muscle strength and explosive performance generally show acute inhibitory trends, consistent with a transient neurophysiological response. Foam rolling appears to have limited direct effects on muscle activation, although it may support recovery-related neuromuscular function in specific settings. It may also alleviate delayed-onset muscle soreness and improve pain-related or hemodynamic responses, but these effects appear to be context-dependent. Its mechanisms involve multifactorial interactions, including myofascial release, mechanoreceptor activation, and hemodynamic regulation. Limitations of existing studies include small sample sizes, heterogeneous intervention protocols, and short follow-up periods. Future research should adopt large-sample, long-term designs to determine optimal intervention parameters and confirm efficacy in clinical populations.