Journal of Innovations in Medical Research

Management of Acute and Chronic Hepatitis B and C Viral Infections

Haradhan Kumar Mohajan — 2025-10-30

Hepatitis is an inflammation of the liver that can be caused by over alcohol and toxin chemical consumption, some medications, and viruses, such as hepatitis B, C, D, and E. The hepatitis B virus (HBV) and hepatitis C virus (HCV) can develop acute and chronic viral infections that are major causes of liver cirrhosis, liver cancer, liver transplantation, and liver related death worldwide. Both of these two viruses can transmit through the vertical or horizontal route, such as blood or body fluids from an infected person, unprotected sex with an infected person, sharing needles with infected person, and from infected mother to baby during birth. Symptoms of both diseases are similar, and some common symptoms are jaundice, loss of appetite, fever, fatigue, dark urine, joint pain, abdominal pain, diarrhea, nausea, and vomiting, etc. The incubation period is 8-20 weeks for hepatitis B, and 2-6 weeks for hepatitis C. At present there are two vaccines of HBV, but no vaccine available for HCV.

Research on Miniaturization and Low-Power Technology of Portable Ventilators in Home Medical Scenarios

Yinglong Jiang — 2025-10-30

This study achieved dual breakthroughs of ≤15 W average power consumption and 8.2 h medium-pressure endurance under extreme geometric constraints of 9.8 L and 2.8 kg, through an integrated architecture of “modular-graphene-micro-fan” and a full-chain low-power model of “brushless motor + intelligent frequency conversion + sleep-wake.” National-level testing showed noise levels of 33 dB, pressure output deviation of ±0.3 cmH₂O, and leak compensation of 185 L min⁻¹. A 50-case, 30-day multicenter home clinical validation indicated a 1.7 mmHg decrease in morning PaCO₂ (non-inferiority achieved), no statistically significant difference in AHI compared to controls, average daily use of 7.9 h, device satisfaction of 90%, and compliance of 96%, with only 5 cases of Grade I adverse events. The results first confirmed that portable ventilators with ≤10 L can achieve equivalent therapeutic outcomes to traditional devices in real-world settings, providing a registrable and industrializable technical paradigm for home respiratory support under the silver economy.

Design and Practice of Elastic Scaling Mechanism for Medical Cloud-Edge Collaborative Architecture

Zhengyang Qi — 2025-11-17

Medical test peaks can triple within a few minutes, while traditional threshold-based scaling lags by 10 minutes and incurs a 45% higher cost, resulting in report delays exceeding 6 hours. This study proposes an integrated mechanism of “edge preprocessing + cloud elasticity + prediction trigger.” The edge filters invalid data in real time and reports the load, while the cloud pool scales up within 5 minutes based on “CPU > 75%” or “Flu-Prophet seasonal prediction.” Docker NS ensures CLIA-compliant hard isolation for multi-tenants. The experiment, based on 41 million real orders, maintained 99.93% availability and stabilized report issuance time at 2.4 hours under a 3.2× peak on Black Friday, with a 22% reduction in cloud bills. This study is the first to embed medical seasonal events into a cloud-edge collaborative closed loop, achieving non-collapse during peaks, cost savings, and compliance for easy replication in grassroots medical clouds.

Research on the Intervention of Cancer Patients’ Anxiety by the Concept of “Harmonization of Body and Mind” in Traditional Chinese Medicine

Dandan Yuan — 2025-11-17

The clinical management of cancer-related anxiety disorders faces significant challenges, with existing pharmacological interventions being limited by delayed efficacy, frequent adverse reactions, and rebound effects upon discontinuation. This study, based on the traditional Chinese medicine (TCM) framework of “harmonization of liver and spleen - emotional regulation,” constructs a standardized intervention module combining the modified Si-Ni-San formula and structured emotional counseling. A multicenter, randomized, double-blind, placebo-controlled clinical trial was conducted at the University of California, Los Angeles (UCLA) Medical Center and the Memorial Sloan Kettering Cancer Center to systematically evaluate its clinical efficacy and safety in patients with moderate anxiety disorders in advanced cancer. A total of 320 patients with stage III/IV lung or breast cancer and moderate anxiety disorders (baseline Hamilton Anxiety Scale [HAM-A] scores of 14-21) were randomly assigned to the intervention group (n=160, Si-Ni-San granules combined with structured emotional counseling) and the control group (n=160, maltodextrin placebo combined with health education). The intervention lasted for 8 weeks, followed by a 4-week follow-up. The primary outcome showed that after 8 weeks of intervention, the HAM-A score in the intervention group decreased from 17.2±2.1 to 8.1±2.0, with a reduction of 9.11±2.04, significantly better than the control group (reduction of 3.42±1.89). The between-group difference was 5.69, and the clinical remission rate (HAM-A ≤10) reached 82.5%. In secondary outcomes, serum cortisol levels decreased by 59.3±12.6 nmol/L, and the psychological function dimension score of the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) increased by 23.2±7.5. Safety analysis indicated that the incidence of adverse reactions in the intervention group was only 6.25%, significantly lower than the control group (18.75%). During the 4-week follow-up, the therapeutic indicators in the intervention group remained stable without rebound upon discontinuation. Mechanistically, the integrated intervention may upregulate the expression of hippocampal 5-hydroxytryptamine 1A receptors and inhibit the activation of the NLRP3 inflammasome through Si-Ni-San, while emotional counseling regulates the hyperfunction of the hypothalamic-pituitary-adrenal axis, achieving a synergistic effect of “harmonization of liver and spleen - emotional regulation - stress relief.” This study provides high-quality evidence-based medical evidence for the integration of TCM body-mind integrated intervention into integrative oncology clinical practice, and its standardized intervention module has the potential for telemedicine promotion.

Neurodevelopmental Perspectives on the Rising ADHD Diagnoses in China

Hao Xu — 2025-11-26

The rising rates of ADHD diagnosis in China reflect a complex interplay between neurodevelopmental vulnerability, evolving diagnostic standards, and sociocultural pressures embedded in the educational and healthcare systems. This paper examines ADHD through a neurodevelopmental lens while situating diagnostic trends within China’s rapidly shifting social context. Neurocognitive evidence shows consistent deficits in attention regulation, inhibitory control, and atypical maturation of prefrontal–striatal circuitry among children with ADHD, patterns that align with findings from Chinese neuroimaging studies. At the same time, increased clinical and public recognition—driven by updated diagnostic guidelines, school monitoring practices, and expanded digital health information—has intensified referral pathways, particularly in urban regions. Prenatal and perinatal factors, including maternal stress, secondhand smoke exposure, preterm birth, and gestational metabolic conditions, further contribute to developmental risk. Environmental exposures such as PM2.5 pollution, lead, sleep disruption, and early screen overuse compound these vulnerabilities. However, diagnostic accuracy remains uneven due to substantial gaps in specialist availability, reliance on brief screening tools, and inconsistent use of standardized instruments across regions. These challenges are amplified by sociocultural dynamics: high academic expectations heighten the visibility and perceived severity of attentional difficulties, while parental anxiety and media-driven interpretations can increase demand for clinical evaluation. To address these issues, the paper proposes a neurodevelopmentally informed diagnostic framework emphasizing early developmental surveillance, standardized multi-step assessments, and strengthened collaboration across school, family, and clinical settings. Enhancing diagnostic consistency and equity will require expanding specialist training, improving access to comprehensive evaluations, and situating behavioral concerns within appropriate developmental and cultural contexts. Such an approach can better support children with attentional and regulatory challenges while mitigating risks of overdiagnosis and misclassification.