Mean Platelet Volume and Cancer-Associated Deep Vein Thrombosis

Authors

  • A. Guiga Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
  • M. Krifa Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
  • A. Amara Department of Family and Community Medicine, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
  • M. Thabet Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
  • W. BenYahia Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
  • A. Atig Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
  • C. Zedini Department of Family and Community Medicine, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia
  • N. Ghannouchi Department of Internal Medicine, Farhat Hached University Hospital, Faculty of Medicine, University of Sousse, 4002 Sousse, Tunisia

Keywords:

mean platelet volume, deep vein thrombosis, cancer, biomarkers, thrombosis, inflammation

Abstract

Background: Deep vein thrombosis (DVT) is a common and serious complication in cancer patients, primarily driven by malignancy-induced hypercoagulability and systemic inflammation. Mean platelet volume (MPV), a hematological parameter reflecting platelet activation and inflammatory status, has been proposed as a potential marker for thromboembolic risk stratification in oncology. Objective: This retrospective study aimed to assess the association between MPV and DVT in patients with underlying cancer. Methods: We analyzed MPV levels in a cohort of 102 patients diagnosed with DVT, including 18 individuals with active malignancy. Results: Although MPV values were slightly elevated in cancer patients compared to non-cancer patients, the difference did not reach statistical significance (p = 0.86). Conclusion: Our findings suggest that MPV is not a reliable biomarker for cancer-associated DVT. Further studies exploring alternative hematological and inflammatory markers are warranted to improve risk assessment in this high-risk population.

Downloads

Published

2025-04-08

How to Cite

A. Guiga, M. Krifa, A. Amara, M. Thabet, W. BenYahia, A. Atig, C. Zedini, & N. Ghannouchi. (2025). Mean Platelet Volume and Cancer-Associated Deep Vein Thrombosis. ournal of nnovations in edical esearch, 4(2), 26–28. etrieved from https://www.paradigmpress.org/jimr/article/view/1594

Issue

Vol. 4 No. 2 (2025): April

Section

Articles