A Case of Undifferentiated Pleomorphic Sarcoma of the Right Lower Extremity

Abstract

Objective: To strengthen the understanding of the disease and treatment of undifferentiated pleomorphic sarcoma (UPS). Methods: The clinical data of an elderly male patient with UPS admitted to Hebei Provincial People’s Hospital in September 2020 were retrospectively analyzed, and relevant literatures were reviewed. Results: The patient was an elderly male, 74 years old. The color Doppler ultrasonography of the body surface mass showed a solid mass of subcutaneous soft tissue on the lateral side of the right thigh. Undirected arrangement, multinucleated tumor giant cells with strange shapes are seen, and mitotic figures are more common. Immunohistochemical staining: CKpan (-), Vimentin (+), Desmin (-), SMA (partial+), EMA (-), S100 (-), CD34 (vascular+), MyoD1 (-), Myogenin (-), Myoglobin (-), CD68 (-), Caldesmon (-), Ki-67 (about 40% active area). After six months of follow-up, no tumor recurrence was found. Conclusion: UPS is a rare malignant tumor in clinic. It has no specific clinical manifestations, imaging manifestations, histopathology and immunohistochemical staining. It is an exclusive diagnosis. Complete tumor resection is required, and pathological examination is the gold standard for diagnosis. Its long-term prognosis is relatively poor.