Complete Recovery of 94 Vaccinated and Non-Vaccinated Cases from COVID-19 Treated at Home with Favipiravir, Dexamethasone, Antibiotics, and Other Supportive Medicines and Care

Abstract

Objective: In 2002-2003 an extraordinary outbreak of coronavirus infection known as Severe Acute Respiratory Syndrome Corona virus or SARS CoV infection occurred in south China and eventually spread in 28 countries around the world with 8096 cases. In December 2019, Corona virus infected disease 19 or COVID-19 or SARS CoV-2 first occurred in Wuhan, South China and rapidly spread all over the world. All the leading viral disease research group and clinical Institutions have been trying hard to find an effective antiviral regime to curve the COVID-19 mortality and morbidity. The preventive vaccinations for COVID-19 are in vogue with mixed response. The objective of this study was to provide treatment for COVID-19 cases at home at the earliest with proper selection and combination of medicines to stop the mortality, morbidity and heavy hospital expenditure. Methods: All the study cases were from Kolkata, India. Considering infectivity and mortality of SARSCoV-2, primarily all the clinical history including clinical data of the cases were collected through mobile media (smart phone). The accumulated data had been recorded in history sheets which were finally completed after the recovery of the cases by personal interview or interview of the family members in case of death. The majority cases were diagnosed by RT-PCR and rest by Rapid antigen test or by symptoms. The study could be labelled as an open label study considering all the facts and figures and outcome involved in the study design of this clinical research. This study included 123 COVID-19 cases, at an age range, 10-85 Years (mean age 48·66±17·69; median age 51 years). Out of these cases, 94 cases between 22-85 years (mean age 50·44±16·83; median age 53years) were selected for home treatment up to 2 weeks with our formulated protocol consisting of Favipiravir, Dexamethasone Antibiotics (Azithromycin/ Clarithromycin or Doxycycline), Pantoprazole and Doxophylline. Out of 94 cases only two cases had experienced little fall of oxygen saturation and treated with oxygen at home and Doxophylline. All the 94 cases treated with the protocol completely recovered after two weeks without any residual symptoms. The rest 29 cases, treated outside in hospitals or clinics and designated as external cases were used for comparison. Results: Out of total of 29 COVID-19 external cases, 25 cases had taken ivermectin for COVID-19 treatment of which 19 cases recovered with various post COVID symptoms. Six cases were unresponsive to ivermectin and were admitted to hospital and out of them one patient expired. All the 94 cases, treated at home by our protocol, had recovered completely from the disease without any residual symptoms and the recovery period was shortened. we found that, our formulated protocol for COVID-19 was an absolute success. Conclusion: From the study it is concluded that COVID-19 cases can be treated effectively at home without any casualty provided that the cases are diagnosed and treated with proper medicines at the earliest.